HL-A-Linked Human Immune-Response Genes

H-2-LINKED IMMUNE RESPONSE (Ir) GENES

Two H-2-linked autosomal dominant immune response (Ir) genes Ir-IgG and Ir-IgA were demonstrated to be at separate loci. Ir-IgG controls the immune response to IgG (gamma2a) myeloma proteins and Ir-IgA the immune response to IgA meyloma proteins. Both genes are associated with the H-2K region specificities of the H-2 chromosome, specifically Ir-IgG with H-2(b) and Ir-IgA with H-2(a). Different ...

Lymphocytes alloantigens associated with X-chromosome-linked immune response genes.

A new polymorphic alloantigen system controlled by loci on the X-chromosome has been identified by using antisera from F1 hybrid mice differing in their X-chromosome. These alloantigens are associated with the X-chromosome. These alloantigens are associated with the X-linked immune response genes controlling the immune response to the so-called "thymus independent antigens" such as type III pne...

Cryptococcal Infection Influence the Immune Response in a Murine Ig Heavy Chain Complex-Linked Genes

Enteroviruses and Type 1 Diabetes: Candidate Genes Linked With Innate Immune Response

In addition to HLA associated genetic predisposition, the role of In addition, PTPN2, a candidate gene for T1D is a negative regulator exogenous factors in the development of type 1 diabetes (T1D) is well admitted. Since many decades, accumulating evidence strongly has supported an association between enteroviruses (EV) and T1D (Hober and Sauter, 2010). Moreover, the potential mechanisms underl...

Rapid evolution of innate immune response genes